NL West rivals square off when the San Diego Padres (4-1) and the San Francisco Giants (2-2) match up on Tuesday night at 9:45 p.m. ET. San Francisco is listed as a -115 favorite (risk $115 to $100) at Caesars Sportsbook, while the Over-Under is set at 7.5 runs (see up-to-date odds for every game this week on our MLB odds page). 

Before making any Padres vs. Giants picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen HUGE returns!

The model knows San Diego has scored four-plus runs in three straight games and ranks tenth in the league in batting average (.256). They also rank fourth in on-base percentage (.350). The Padres have driven in 21 runs through five games and first baseman Eric Hosmer has a batting average of .533 and eight total hits. 

The model also knows San Francisco hasn't allowed more than four runs in three straight games. Their pitching has been solid thus far, ranking 10th in the league in ERA (3.16) while striking out 40 total batters. Right-hander Alex Cobb is making the start for the Giants and produced a solid campaign last year. He was 8-3 with a 3.76 ERA and 98 strikeouts. 

Now, it has set its sights on Padres vs. Giants. We can tell you the model is leaning over the total, and it also says one side of the money line hits in over 60 percent of simulations. You ABSOLUTELY need to see it before locking in any MLB picks.

So who wins Padres vs. Giants? And which side of the money line hits in over 60 percent of simulations? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks!