The Baltimore Orioles and the Toronto Blue Jays begin the 2025 season with an AL East contest on Thursday. The Orioles went 91-71 last season and made the postseason. Meanwhile, the Blue Jays were 74-88 in their previous campaign. Zach Eflin (0-1, 5.40 ERA) starts for Baltimore. Jose Berrios (2-0, 2.18 ERA) is on the hill for Toronto. 

First pitch is scheduled for 3:07 p.m. ET at the Rogers Centre in Toronto, Canada. The Blue Jays are the -116 money-line favorites (bet $116 to win $100) in the latest Orioles vs. Blue Jays odds, while the Orioles are -104 underdogs (bet $104 to win $100). The over/under for total runs scored is 8.5 in the latest MLB odds via SportsLine consensus. 

Before you make any Orioles vs. Blue Jays picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

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The model has simulated Orioles vs. Blue Jays 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

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