The No. 5 Oregon Ducks (24-9) will face the No. 12 Liberty Flames (28-6) in a 2025 NCAA Tournament East Region matchup on Friday. The Ducks impressed in their first season in the Big Ten, going 12-8 in conference play. They will face a Flames side that topped Conference USA with a 13-5 record and ended the season on a five-game winning streak.

Tip-off from Climate Pledge Arena in Seattle is set for 10:10 p.m. ET. The Ducks are 6.5-point favorites in the latest Oregon vs. Liberty odds via SportsLine consensus, while the over/under for total points is 137.5.

Before making any Oregon vs. Liberty picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Oregon vs. Liberty 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Oregon vs. Liberty, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!