The Oregon Ducks will take on the Fresno State Bulldogs at 2 p.m. ET on Saturday at Autzen Stadium. The Ducks ended last year second in the Pac-12's North Division, while Fresno State ended up fifth in the West Division of the Mountain West Conference. Fresno State was one of the handful of teams who played in Week 0 as it demolished UConn 45-0.

The Ducks are favored by 20.5 points in the latest Oregon vs. Fresno State odds from Caesars Sportsbook, and the over-under is set at 64. Before you make any Oregon vs. Fresno State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Oregon vs. Fresno State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oregon vs. Fresno State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!