The SEC and ACC square off on Thursday as the Duke Blue Devils (9-3) take on the No. 14 Ole Miss Rebels (9-3) in the 2025 Gator Bowl. The Rebels were one of the last teams left out of the CFP field and outgoing quarterback Jaxson Dart is looking to put up one more big showing under coach Lane Kiffin. Duke, meanwhile, won its last three games but will be without its top two quarterbacks (transfer portal) in this one.

Kickoff is at 8 p.m. ET, 30 minutes later than originally scheduled, from EverBank Stadium in Jacksonville, Fla. The Rebels are 17-point favorites in the latest Ole Miss vs. Duke odds via SportsLine consensus, while the over/under is 50.5.

Before making any Ole Miss vs. Duke picks, you NEED to see what SportsLine college football expert Eric Cohen has to say.

Cohen, host of the weekly Early Edge College Football Picks Show on CBS Sports Network, is 74-54 on college football picks this season, returning more than $1,500 for $100 bettors. Anyone who has followed Cohen's CFB predictions is up BIG!

Now, Cohen has analyzed Duke vs. Ole Miss from every angle and just locked in his picks and predictions.

He's found a critical 10-2 betting trend that has him zeroing in on a must-see best bet! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Duke vs. Ole Miss on Thursday, and what critical betting trend do you need to know about? ... Join SportsLine right now to see the best bet for Duke vs. Ole Miss, all from the football expert who is 74-49 (+2097) on his CFB picks this season!