The No. 2 Ohio State Buckeyes will return home following a crucial victory when they host the Purdue Boilermakers on Saturday afternoon. Ohio State is coming off a 20-13 win at then-No. 3 Penn State, improving to 7-1 and staying in contention for the Big Ten title. Purdue is riding a seven-game losing streak and is coming off a 26-20 loss to Northwestern in overtime last week. 

Kickoff is set for noon ET on Saturday at Ohio Stadium. Ohio State is favored by 37.5 points in the latest Ohio State vs. Purdue odds, while the over/under is 54 points, per SportsLine consensus. Before entering any Purdue vs. Ohio State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has simulated Ohio State vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations!

So who wins Ohio State vs. Purdue, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!