One of college football's most anticipated matchups of the season takes place on Saturday when the No. 3 Oregon Ducks host the No. 2 Ohio State Buckeyes at Autzen Stadium. Oregon is 5-0 overall and 3-0 at home, while Ohio State is 5-0 overall and 1-0 on the road. The winner of this Big Ten battle will be in prime position to make the College Football Playoff. 

Saturday's showdown gets underway at 7:30 p.m. ET. The Buckeyes are favored by 3.5 points in the latest Ohio State vs. Oregon odds via SportsLine consensus, and the over/under is 53 points. Before entering any Oregon vs. Ohio State picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks since inception, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen STRONG returns!

The model has simulated Ohio State vs. Oregon 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations!

So who wins Oregon vs. Ohio State, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the advanced computer model that has crushed its college football picks!