The No. 3 Ohio State Buckeyes will aim for their third consecutive blowout win to open the season when they host the Marshall Thundering Herd on Saturday afternoon. Ohio State picked up a 52-6 win over Akron and a 56-0 win over Western Michigan before having the week off last week. Marshall is coming off its bye week as well, which was timely following a 31-14 loss at Virginia Tech. 

Kickoff is set for noon ET on Saturday at Ohio Stadium. Ohio State is favored by 40 points in the latest Ohio State vs. Marshall odds, while the over/under is 52.5 points, per SportsLine consensus. Before entering any Marshall vs. Ohio State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 5-2 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model has simulated Ohio State vs. Marshall 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations!

So who wins Ohio State vs. Marshall? And which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!