The Big Ten on CBS kicks off Saturday when No. 3 Ohio State and Indiana clash in the season and conference opener for both sides. The Buckeyes have been regular playoff contenders in recent years and they're coming off an 11-2 campaign last season. Indiana, meanwhile, is looking to bounce back from a 4-8 season in 2022. 

Kickoff is 3:30 p.m. ET at Memorial Stadium in Bloomington, Ind. The Buckeyes are 30-point favorites in the latest Ohio State vs. Indiana odds from the SportsLine consensus, while the over/under for total points scored is 59 (See up-to-date odds for every game this week on our college football odds page.) 

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can get 50% off for one year from now until 9/20/23.

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Before making any Ohio State vs. Indiana picks or college football predictions, see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has factored in that Ohio State is coming off another CFP appearance and the Buckeyes came within a point of knocking off powerhouse Georgia in the national semifinals last season. They will have to replace star quarterback C.J. Stroud, but they return elite receiver Marvin Harrison Jr., among other key players. 

This, however, is a big number to cover on the road in a Big Ten road game. Ohio State didn't have any road wins of 30 or more points last season and Indiana hit the transfer portal hard in the offseason looking for upgrades, giving the Hoosiers a great chance to keep this one within the spread. 

Now, the model has set its sights on Ohio State vs. Indiana. We can tell you it is leaning Under the total, and it also says one side of the spread hits more than 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Ohio State vs. Indiana, and which side of the spread hits more than 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over Saturday, all from the model that's up nearly $2,500 all time on its top-rated college football spread picks!