The No. 2 Ohio State Buckeyes will face the unbeaten No. 5 Indiana Hoosiers in a Big Ten showdown on Saturday afternoon. Ohio State won its fourth consecutive game last week, cruising to a 31-7 win over Northwestern. Indiana had an extra week to prepare for this game after beating Michigan two weeks ago, which should be useful as it faces a ranked team for the first time this season.   

Kickoff is set for noon ET on Saturday at Ohio Stadium. Ohio State is favored by 10.5 points in the latest Ohio State vs. Indiana odds, while the over/under is 52 points, per SportsLine consensus. Before entering any Indiana vs. Ohio State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a strong 21-15 on all top-rated picks over the past eight weeks of this season. Anyone following at sportsbooks and on betting apps has seen STRONG returns!

The model has simulated Ohio State vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 50% of simulations!

So who wins Ohio State vs. Indiana, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!