The Notre Dame Fighting Irish (22-10) and the Rutgers Scarlet Knights (18-13) square off in the 2022 NCAA Tournament on Wednesday night in one of the First Four matchups. Notre Dame is favored by one point, while the Over-Under is set at 132 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Notre Dame vs. Rutgers picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Rutgers senior guard Ron Harper Jr. is putting up 15.6 points and 5.9 rebounds per game. Harper Jr. is a threat on the perimeter, shooting 39 percent from 3-point land. The New Jersey native has scored 19 points in two of his last five games. On Mar. 2 against Indiana, Harper Jr. had 19 points, six rebounds and knocked down five 3-pointers. 

The model also knows Notre Dame freshman guard Blake Wesley averages 14.6 points, 3.6 rebounds, and 2.5 assists per game. Wesley is fearless when attacking the rim. The Indiana native scored at least 15 points in five of his last eight games. In the Feb. 26 contest against Georgia Tech, he tallied 15 points, four rebounds, and went 5-for-9 from the floor. 

Now, it has set its sights on Notre Dame vs. Rutgers. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Notre Dame vs. Rutgers? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of Notre Dame vs. Rutgers spread you should be all over Wednesday, all from the model on a roll on college basketball picks!