The biggest upset of the 2024 college football season up to this point, and a strong candidate to finish as the upset of the season, occurred last weekend when Notre Dame lost to Northern Illinois, 16-14, in South Bend. Notre Dame was favored by more than four touchdowns in that contest. Notre Dame dropped from No. 5 to No. 18 in the country as the Fighting Irish look to return to their winning ways against the Purdue Boilermakers on Saturday. Purdue defeated Indiana State, 49-0, on August 31 in its only game of the season.

Kickoff is scheduled for 3:30 p.m. ET at Purdue's Ross-Ade Stadium in Indiana. Notre Dame is a 7.5-point favorite in the latest Notre Dame vs. Purdue odds, while the over/under for total points scored is 47, according to the latest Purdue vs. Notre Dame odds from the SportsLine consensus. Saturday's showdown can be seen live on CBS and streamed live on Paramount+. (See up-to-date odds for every game this week on our college football odds page.)

Before making any Notre Dame vs. Purdue picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model knows despite last weekend's upset loss, Notre Dame opened the season with a 23-13 victory over No. 20 Texas A&M at College Station. The Fighting Irish have one of the most dominant defenses in the country, allowing just 14.5 points per game this season. It also knows sophomore running back Jeremiyah Love is off to a strong start, rushing for 170 yards on 6.8 yards per carry over Notre Dame's first two games.

The model also knows that Purdue returns quarterback Hudson Card, who had a near-perfect first game of the season. He completed 24 of 25 passes for 273 yards and four touchdowns in Week 1. The fifth-year senior threw for 2,387 yards and 15 touchdowns with eight interceptions last year after spending his first three years at Texas. Purdue held Indiana State to 154 total yards in its 49-0 victory.

For Saturday, the model has set its sights on Purdue vs. Notre Dame. We can tell you it is leaning Over the total, projecting 51 combined points. It also says one side of the spread hits nearly 60% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Notre Dame vs. Purdue, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the Purdue vs. Notre Dame spread you should be all over Saturday, all from the model on a roll on college football picks!