The 2025 ACC Tournament begins on Tuesday when the No. 12-seeded Notre Dame Fighting Irish (14-17) play the No. 13-seeded Pittsburgh Panthers (17-14) in the first round of the conference tournament. Both teams will need to win the ACC Tournament outright to make the NCAA Tournament, and the winner advances to play No. 5 seed North Carolina on Wednesday. 

Tip-off is set for 2 p.m. on Tuesday from the Spectrum Center in Charlotte, N.C. Pittsburgh is favored by 3.5 points in the latest Pittsburgh vs. Notre Dame odds, while the over/under is 136.5 points per SportsLine consensus. 

Before entering any Pittsburgh vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Pittsburgh vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Pittsburgh vs. Notre Dame, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!