The No. 7 seed Notre Dame Fighting Irish will try to advance to the quarterfinals of the College Football Playoff when they face the No. 10 seed Indiana Hoosiers in the first round on Friday night. Notre Dame went 11-1 this season with its only loss coming in a shocking upset against Northern Illinois, falling 16-14 as 27.5-point favorites on Sept. 7. Indiana has been one of the best stories in college football, smashing its preseason over/under total en route to going 11-1 overall, including 8-1 in the Big Ten.

Kickoff is set for 8 p.m. ET on Friday at Notre Dame Stadium in South Bend, Ind. Notre Dame is favored by 7 points in the latest Indiana vs. Notre Dame odds, while the over/under is 51 points, per the SportsLine consensus. Before entering any Notre Dame vs. Indiana picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it went a profitable 43-34 on top-rated picks during the 2024 regular season. Anyone following at sportsbooks and on betting apps has seen impressive returns!

The model has simulated Notre Dame vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Notre Dame? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.