The Northwestern Wildcats attempt to extend one streak and end another when they host the Duke Blue Devils at Northwestern Medicine Field at Martin Stadium in Evanston, Ill. on Friday. Northwestern (1-0) began its 2024 campaign with its fifth consecutive victory dating back to last season, a 13-6 home triumph over Miami (OH). However, the Wildcats have lost their last five meetings with Duke and trail 13-10 in the all-time series. The Blue Devils (1-0) are seeking their third straight 2-0 start to a season after cruising past Elon 26-3 in their opener.

Kickoff is scheduled for 9 p.m. ET. The Wildcats are 1.5-point favorites in the latest Northwestern vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 37. Before making any Duke vs. Northwestern picks or CFB predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It also is coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen STRONG returns!

The model knows Northwestern has won three straight non-conference games for the first time since 2016-17 and is looking for its first six-game overall winning streak since 2019-20. Quarterback Mike Wright led the Wildcats offensively in its season-opening victory, completing 18-of-30 pass attempts for 178 yards while rushing for a team-high 65 yards and their lone touchdown. The defense played a major role in the win, limiting Miami (OH) to 40 yards on the ground while recording four sacks and two interceptions as Northwestern did not allow a TD for the first time since its 2020 season opener against Maryland.

The model has also taken into account that Duke also came up with a strong defensive effort in its first game of the year. The Blue Devils permitted just 140 total yards, including 30 rushing, while registering eight sacks and 16 tackles for loss against Elon. Quarterback Maalik Murphy threw for 291 yards and a pair of touchdowns in his debut with Duke after transferring from Texas, while wideout Jordan Moore hauled in seven passes for 112 yards.

The model has simulated Northwestern vs. Duke 10,000 times and the results are in. We can tell you the model is leaning Over on the total, and it also says one side of the spread hits well over 60% of the time!

Who wins Duke vs. Northwestern, and which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 13-9 roll on top-rated CFB picks!