The No. 9 Kansas Jayhawks (12-3) and the No. 2 Iowa State Cyclones (14-1) square off in a Big 12 contest on Wednesday night. The Cyclones are rolling right now, winning 11 straight games. They beat Texas Tech 85-84 in an overtime bout on Saturday. Meanwhile, the Jayhawks are on a three-game win streak. Kansas beat Cincinnati topped Cincinnati 54-40 on Jan. 11. 

Tipoff is scheduled for 7 p.m. ET at James H. Hilton Coliseum in Ames, Iowa. The Cyclones are 5.5-point favorites in the latest Kansas vs. Iowa State odds from SportsLine consensus, while the over/under for total points scored is 144.5. 

Before entering any Kansas vs. Iowa State picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 11 of the 2024-25 season on a 195-134 roll (+2882) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits 50% of the time!

So who wins Kansas vs. Iowa State, and which side of the spread hits in 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!