No. 6 Villanova (4-2) goes on the road to take on the Pennsylvania Quakers (3-6) in a matchup on Wednesday night at 7 p.m. ET. The Wildcats are coming off a dominant victory against La Salle University. They beat the Explorers 72-46 in a rout on Sunday night. Pennsylvania is currently on a two-game losing streak, dropping their last game to No. 10 Arkansas 76-60. Villanova is favored by 18 points at Caesers Sportsbook, while the Over-Under is set at 138. 

Before making any Villanova vs. Pennsylvania picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.  

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Villanova guard Collin Gillespie is second on the team in points (15.5), first in assists (4.2), and first in steals (1.7). Gillespie scored double-digit points and knocked down at least two 3-pointers in every matchup thus far. The Pennsylvania native has also swiped away at least two steals in four games this season. Gillespie had an all-around game against La Salle. He finished with 13 points, six rebounds, five assists, and knocked down three 3-pointers. 

The model also knows sophomore guard Jordan Dingle is Pennsylvania's leading scorer with 19.6 points per game with 3.3 rebounds and 3.3 assists. Dingle has scored at least 20 points in four games this year. His best outing came against Utah State, where he recorded 31 points with five rebounds and four assists. 

Now, it has set its sights on Villanova vs. Pennsylvania. We can tell you the model is leaning over the total, and it also says one side of the spread has hits in almost 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Villanova vs. Pennsylvania? And which side of the spread hits in almost 70 percent of simulations? ... Join SportsLine right now to find out which side of the Villanova vs. Pennsylvania spread you should be all over Wednesday, all from the model on a roll on college basketball picks!