The sixth-seeded Penn State Nittany Lions will battle the third-seeded Boise State Broncos in the College Football Playoff quarterfinals at the Fiesta Bowl on Tuesday night. The winner of the game will then face the winner of seventh-seeded Notre Dame and second-seeded Georgia in the semifinals. Penn State (12-2) will be without at least seven players due to injury or the transfer portal, while Boise State (12-1) will be missing at least 12.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 7:30 p.m. ET. The Nittany Lions are 12.5-point favorites in the latest Penn State vs. Boise State odds, while the over/under for total points scored is 54.5. Penn State is -526 on the money line (risk $526 to win $100).

Before making any Penn State vs. Boise State picks or college football predictions, you NEED to hear what SportsLine college football expert Adam Silverstein has to say.

CBS Sports' managing editor, Silverstein is on a 15-2 run on his last 17 selections (+1275) in games involving the Nittany Lions. Anyone who has followed him is WAY up!

Now, Silverstein has analyzed Penn State vs. Boise State from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Penn State vs. Boise State on Tuesday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Penn State vs. Boise State spread to jump on, all from the football expert who is 15-2 (+1275) on his last 17 Penn State picks!