The fourth-ranked Penn State Nittany Lions attempt to maintain their unbeaten record when they host the Indiana Hoosiers in a Big Ten Conference contest on Saturday. Penn State (4-0, 1-0 Big Ten) is coming off a 38-17 victory over Villanova, while Indiana (2-2, 0-1) edged Western Kentucky 33-31 on the road last weekend.

Kickoff from Beaver Stadium in University Park, Penn. is set for 7:30 p.m. ET. The Nittany Lions are 12-point favorites in the latest Penn State vs. Indiana odds from Caesars Sportsbook, while the Over-Under for total points scored is 53.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before making any Indiana vs. Penn State picks or college football predictions, see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

The model knows Penn State possesses a defense that makes it difficult for opponents to get on the scoreboard. The Nittany Lions allow an average of 15 points per game, which ranks them 12th in the nation. On the other side of the ball, Penn State is 18th in the country in passing (307.8 yards) thanks to senior quarterback Sean Clifford, who threw for a career-high 401 yards in last week's 38-17 win against Villanova.

The model also knows Indiana is capable offensively, as it has scored 24 or more points in three of its four games this season. The Hoosiers amassed 507 total yards in last week's 33-31 triumph at Western Kentucky as junior quarterback Michael Penix Jr. had 373 passing yards and ran for a touchdown. Indiana ended its six-game losing streak against Penn State in 2020, posting 36-35 overtime victory in its season opener.

Now the model has simulated Penn State vs. Indiana 10,000 times, and the results are in. We can tell you that the model is projecting Under on total points, and it has generated a point-spread pick that is hitting in nearly 60 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the matchup between Penn State and Indiana? And which side of the spread is hitting in nearly 60 percent of simulations? ... Join SportsLine right now to see which side of the Indiana vs. Penn State spread you need to jump on Saturday, all from the computer model that has crushed its college football picks!