The No. 3 Duke Blue Devils (22-3) and the Virginia Cavaliers (13-12) battle in an ACC matchup on Monday. Duke routed Stanford 106-70 in its last contest for its second straight win. Meanwhile, the Cavaliers beat Virginia Tech 73-70 this past Saturday for their third consecutive win. 

Tip-off is scheduled for 8 p.m. ET at John Paul Jones Arena in Charlottesville, Virginia. The Blue Devils are 13.5-point favorites in the latest Duke vs. Virginia odds from SportsLine consensus, while the over/under for total points scored is 131.5. The Blue Devils are -1370 (risk $1370 to win $100) money-line favorites. 

Before entering any Duke vs. Virginia picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 16 of the 2024-25 season on a 213-158 roll (+1675) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 50% of simulations!

So who wins Duke vs. Virginia, and which side of the spread hits in over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!