No. 21 Houston (11-1) and No. 4 Cincinnati (12-0) face off in the American Athletic Conference Championship game on Saturday afternoon. The Cougars dropped their first game of the season to Texas Tech 38-21. Houston has then reeled off an 11-game win streak. Their last game was a 45-17 blowout victory against UConn. The Bearcats have been dominant all year long. Cincinnati is on a 12-game win streak and is currently in the top four of the College Football Playoff rankings.

Kickoff from Nippert Stadium is set for 4 p.m. ET. Cincinnati is favored by 10.5 points in the latest Houston vs. Cincinnati odds from Caesars Sportsbook, while the Over-Under is set at 52.5 points. 

Before making any Houston vs. Cincinnati picks, you'll want to see the college football predictions from the SportsLine Projection Model. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Houston vs. Cincinnati 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it also says one side of the spread hits in over 60 percent of simulations. You absolutely need to see it before locking in your own picks!

So who wins Houston vs. Cincinnati? And which side of the spread hits in over 60 percent of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.