The 12th-ranked Duke Blue Devils meet the Virginia Tech Hokies in a key Atlantic Coast Conference matchup set to tip at 7 p.m. ET on Monday at the Cassell Coliseum in Blacksburg, Va. Duke is 15-4 overall and 3-2 on the road, while Virginia Tech is 13-7 overall and 10-1 at home. The Blue Devils are favored by 3 points in the latest Duke vs. Virginia Tech odds, and the over/under is 146 points.

Before entering any Duke vs. Virginia Tech picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the 2023-24 season on a 114-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 19-5 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model knows sophomore center Kyle Filipowski, a preseason Associated Press All-American, helps power the Blue Devils. In 19 games, all starts, he is averaging 17.7 points, 8.7 rebounds and three assists in 30.1 minutes of action. He became the first Duke player in 40 seasons with a 30-point double-double and no turnovers in an 84-79 win over Georgia Tech on Jan. 13.

It is also aware junior guard Sean Pedulla sparks the Hokies offense. In 18 games played, all starts, he is averaging 15.7 points, 4.4 assists and 4.1 rebounds in 30.6 minutes of action. He is also connecting on 42.5% of his field goals, including a red-hot 39.2% from 3-point range, and 81.2% from the foul line. He has two double-doubles in 2023-24, including a 33-point and 10-rebound performance in a 75-71 loss to Miami on Jan. 13.

The model has simulated Duke vs. Virginia Tech 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Duke vs. Virginia Tech, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!