The 121st edition of the "Palmetto Bowl" takes place when the No. 12 Clemson Tigers host the 15th-ranked South Carolina Gamecocks at Memorial Stadium on Saturday. Clemson (9-2, 7-1 ACC), which trounced The Citadel 51-14 last weekend, owns a commanding 73-43-4 lead in the all-time series and has won eight of the last nine installments - including a 16-7 road triumph last season. South Carolina (8-3, 5-3 SEC), which split its first six games of the season but has won its last five after routing Wofford 56-12 last Saturday, came away with a 31-30 victory in its most recent visit to Clemson in 2022.

Kickoff is scheduled for noon ET. The Tigers are 2.5-point favorites in the latest Clemson vs. South Carolina odds from SportsLine consensus, while the over/under for total points scored is 49.5. Before making any South Carolina vs. Clemson picks or CFB predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It also is a strong 27-17 on all top-rated picks over the past nine weeks of this season. Anyone who has followed it has seen STRONG returns!

The model knows Clemson, which will clinch a spot against SMU in the ACC Championship Game if Miami loses to Syracuse on Saturday, is looking to become the first power conference team since Arkansas in 2006 to record 10 wins after losing its season opener by 30 or more points. The Tigers, who outgained South Carolina 219-57 on the ground en route to a 16-7 victory last year, are 11th in the nation with an average of 37.6 points in 2024 and have outscored their opponents 411-208 since being trounced by Georgia 34-3 in their first game of the campaign. Junior quarterback Cade Klubnik is fourth in FBS with 29 touchdown passes and has thrown at least three in seven of the team's 11 contests.

The model also has taken into account that South Carolina has posted five consecutive wins for the first time since 2013, with four of the triumphs coming by 21 or more points. The Gamecocks are looking to record four straight victories against ranked opponents for the first time since 1980 and four road wins in a season for just the second time this century (four in 2006). Redshirt freshman quarterback LaNorris Sellers has registered back-to-back 300-yard passing performances, throwing a total of eight TD passes in those outings, and ranks second on the team with 489 rushing yards and five scoring runs.

The model has simulated South Carolina vs. Clemson 10,000 times and the results are in. We can tell you the model is leaning Over on the total, and it also says one side of the spread hits well over 50% of the time!

Who wins Clemson vs. South Carolina, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is 27-17 on top-rated CFB picks over the past nine weeks!