After a perfect season and a conference championship in their first season in the Big Ten, the Oregon Ducks earned the No. 1 seed in the College Football Playoff and now Dan Lanning's squad will begin their title pursuit coming off a bye week. However, the committee did them no favors, as they'll take on the No. 8 Ohio State Buckeyes in the quarterfinals at the 2025 Rose Bowl on Wednesday. Ohio State gave Oregon its toughest test of the season, with the Ducks surviving a 32-31 battle in Eugene during the regular season.

Now the rematch will take place on hallowed ground at the Rose Bowl in Pasadena, Calif. and kickoff is scheduled for 5 p.m. ET. Fresh off a throttling of Tennessee in the first round, the Buckeyes are 2.5-point favorites in the latest Oregon vs. Ohio State odds via SportsLine consensus, while the over/under for total points scored is 55.5. Ohio State is -142 on the money line (risk $142 to win $100) while Oregon is +120.

Before making any Ohio State vs. Oregon picks or college football predictions, you NEED to hear what SportsLine college football expert Adam Silverstein has to say.

CBS Sports' managing editor, Silverstein is on a 7-0-1 run on his last 8 selections (+700) in games involving the Ducks. Anyone who has followed him is WAY up!

Now, Silverstein has analyzed Oregon vs. Ohio State from every angle and just locked in his picks and predictions.

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Ohio State vs. Oregon on Wednesday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Oregon vs. Ohio State spread to jump on, all from the football expert who is 7-0-1 (+700) on his last 8 Oregon picks!