When the Week 6 NFL lines were first posted, 10 of the 14 road teams were favored. That includes the Texans vs. Patriots (+7), Steelers vs. Raiders (+3) and Bengals vs. Giants (+3.5). That could create three Week 6 NFL parlay picks since home underdogs are always tempting to get behind, both against the spread and straight-up. Which home NFL underdogs should warrant your NFL bets as we approach the one-third mark of the 2024 NFL season?

Which NFL trends and NFL betting lines could help with your NFL betting strategy? Before you make any Week 6 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 84-57-3 (59.6%, +20.90 units) since its inception in 2022. Anyone who has followed him is WAY UP!

For Week 6, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Titans (-2.5, 43.5) to cover against the Colts. "Over the last 42 plays of their loss to Jacksonville, the Colts gave up 419 yards, nearly 10 yards a play. This is the ultimate get-right spot for a Titans' offense that is sticking with Will Levis" Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 6 bets, including backing an underdog versus an opponent missing a "difference-maker" due to injury. You ABSOLUTELY need to see his picks before betting on NFL Week 6.

So what are Hartstein's Week 6 NFL best bets? And which team shocks the NFL? ... Join SportsLine right now to see Larry Hartstein's Week 6 NFL best bets, all from the expert who is up 20.90 units on NFL ATS picks!