Three games have Week 4 NFL spreads of at least a touchdown, including Jets vs. Broncos (+7.5), Chiefs vs. Chargers (+7) and 49ers vs. Patriots (+10.5). That provides an appealing slate to combine picks from all three NFL matchups into Week 4 NFL parlay picks. Coincidentally, none of the three big favorites have better spread records this year than their Week 4 opponents, so should you back NFL underdogs in your NFL best bets?

Which NFL trends and NFL tendencies could help with your NFL betting strategy? Before you make any Week 4 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 83-52-3 (61.5%, +25.50 units) since its inception in 2022. Hartstein went 2-1 last week, and anyone who has followed him is WAY UP!

For Week 4, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Steelers (-2, 40) to cover against the Colts. "Edge Nick Herbig (two sacks vs. Chargers) is a rising star on a unit that gives up 8.7 points per game. Look for Pittsburgh to force Anthony Richardson (six INTs, two fumbles) into turnovers and improve to 4-0," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 4 bets, including backing one team whose quarterback "typically thrives in this matchup." You ABSOLUTELY need to see his picks before betting on NFL Week 4.

So what are Hartstein's Week 4 NFL best bets? And which team surprises in Week 4? ... Join SportsLine right now to see Larry Hartstein's Week 4 NFL best bets, all from the expert who is up 25.50 units on NFL ATS picks!