After just one spread of more than 5.5 points in Week 1, there are seven games with NFL spreads of six or more in the Week 2 NFL odds. That includes 49ers vs. Vikings (+4.5), Chiefs vs. Bengals (+6), the SNF contest of Texans vs. Bears (+6.5) and the MNF matchup of Eagles vs. Falcons (+6). Combining picks from some of these games into a Week 2 NFL parlay could be a lucrative decision. Before you make any Week 2 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 81-49-2 (62.3%, +26.85 units) since its inception in 2022. He went 2-1 last week, and anyone who has followed him is WAY UP!

For Week 2, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Seahawks (-3.5) to cover against the Patriots. "Under Mike Macdonald, Seattle held Denver to 3.3 yards per play [in Week 1]. Ryan Grubb's offense got going late with 17 second-half points. Lay the field goal," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 1 NFL picks, including an underdog coming off a loss that he expects to "make adjustments" and grind out a strong Week 2 victory! You ABSOLUTELY need to see his picks before betting on NFL Week 2.

So what are Hartstein's Week 2 NFL best bets? And which team surprises in Week 2? ... Join SportsLine right now to see Larry Hartstein's Week 2 NFL best bets, all from the expert who is up 26.85 units on NFL ATS picks!