Six road teams are laying points in the Week 10 NFL lines. Bills vs. Colts features Buffalo favored by 3.5 in the NFL odds, while Vikings vs. Jaguars has Minnesota also favored by 6.5 on the road. The 49ers are favored by 6.5 against the Buccaneers in the latest NFL spreads, while the Eagles are laying 7.5 at Dallas. In the 2024 NFL season, road favorites have covered at a 65% clip, one of the NFL betting trends to keep in mind before making any Week 10 NFL picks.

Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 10 of the 2024 NFL season, and the results are in.

We can tell you one of the model's strongest Week 10 NFL picks is that the Jaguars (+7, 43.5) cover the spread at home versus the Vikings. Jacksonville wins outright, per the model, which says the Jaguars cover well over 60% of the time. Another one of its Week 10 NFL predictions: the Texans (+3.5, 49.5) cover at home versus the Lions in well over 50% of simulations. The model also says the Over (49.5) hits in over 50% of simulations.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FOUR TEAMS that win outright at least 70% of the time! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 10, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 195-136 roll on top-rated NFL picks!