Week 1 of the 2022 NFL season features multiple mouthwatering matchups, including Steelers vs. Bengals, Packers vs. Vikings, Chiefs vs. Cardinals and Cowboys vs. Buccaneers. The reigning AFC champion Bengals are 6.5-point favorites against the Steelers in the latest Week 1 NFL odds from Caesars Sportsbook. Meanwhile, the Packers are -1.5 against the Vikings, the Chiefs are -6.5 against the Cardinals and the Bucs are -1.5 versus Dallas.

Before making any NFL picks for Week 1, be sure to see what the SportsLine Projection Model has to say. 

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up!

Now, the model has evaluated the latest odds from Caesars, simulated every snap for Week 1 of the 2022 NFL season, and the results are in. 

We can tell you one of the model's strongest Week 1 NFL picks is that the Vikings (-1.5) cover against the Packers in well over 50 percent of simulations. Another one of its Week 1 NFL predictions: The Colts (-7) cover the spread on the road versus the Texans nearly 60 percent of the time. The model also says the Over (44) hits in over 50 percent of simulations.  

The model has also made the call on who wins and covers every other NFL game this week and has identified a Super Bowl contender that goes down HARD! You ABSOLUTELY need to see its NFL picks for every single game before locking in your own.

So which NFL teams should you back this week? And which Super Bowl contender goes down? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $7,500 in profit on top-rated picks since its inception!