The lead in the NFC West will be on the line when the San Francisco 49ers and Seattle Seahawks (+7) collide on Thanksgiving Day at 8:20 p.m. ET. The game is one of three on the NFL schedule for Thanksgiving. Elsewhere around the league, the NFC North-leading Lions and the rival Packers (+8.5) get the day started in Detroit at 12:30 p.m. ET, and the Cowboys and Commanders (+13.5) will renew their rivalry at AT&T Stadium at 4:30 p.m. ET. In college football, the 2023 Egg Bowl takes center stage with No. 13 Ole Miss favored by 10 points against Mississippi State in a 7:30 p.m. ET matchup.

Before you make any Thanksgiving football predictions, you need to see what the SportsLine Projection Model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 11 of the 2023 NFL season on an incredible 174-125 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-17 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. And in college football, the model is up well over $2,000 on its top-rated spread picks all-time.

Now, the model has set its sights on the four NFL Thanksgiving Day games and has generated a four-leg parlay that would pay around 12-1. We can tell you that one of the picks is the Packers to cover against the Lions in a 12:30 p.m. ET kickoff.

The model also locked in three other best bets for Thanksgiving Day NFL 2023. If the parlay hits, you're looking at an epic 12-1 payout. You ABSOLUTELY need to see it before locking in any football picks or parlays of your own.

So what other picks do you need to include in your parlay for a payout of around 12-1? ... Join SportsLine right now to find out which picks you should be all over on Thanksgiving, all from the model that's on an incredible 174-125 NFL run and is up well over $2,000 on top-ranked college football spread picks!