The Buffalo Bills will try to bounce back from their second loss of the season when they face the Minnesota Vikings on Sunday afternoon. Buffalo had its four-game winning streak snapped in a 20-17 loss to the Jets last week, despite being a 10.5-point favorite in that game. The Bills are 3.5-point favorites against Minnesota in the latest Week 10 NFL odds at Caesars Sportsbook given uncertainty surrounding star quarterback Josh Allen (elbow). 

Before making any Week 10 NFL office pool picks, you NEED to see which teams the SportsLine Projection Model is backing in its NFL football pool picks.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

In Week 10, we can tell you the model is extremely high on the New York Giants defeating the Houston Texans. In fact, the model is projecting a 24-15 win for the Giants, who get up the straight-up victory in 71% of simulations.

The model is also calling for several favorites to struggle more than expected and several surprising teams to hang tough! Picks like those can give you a HUGE edge in your pools. You ABSOLUTELY need to see which team the model is backing before locking in your NFL office pool picks!

So which teams win outright in Week 10? And which favorite underdogs should you back? ... Join SportsLine right now to see the optimal NFL office pool picks, all from the model that consistently crushes the NFL and has ranked in the top 10 on NFLPickWatch four of the past six years!