The No. 7 seed Marquette Golden Eagles and the No. 10 seed New Mexico Lobos match up in the first round of the 2025 NCAA Tournament on Friday. The Golden Eagles went 23-10 in the regular season and dropped three of their last four games. On the flip side, New Mexico finished the campaign with a 26-7 record. 

Tipoff from the Rocket Arena in Cleveland, Ohio, is set for 7:25 p.m. ET. Marquette is a 4-point favorite in the latest New Mexico vs. Marquette odds from SportsLine consensus, while the over/under for total points scored is 152.5.

Before making any New Mexico vs. Marquette picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated New Mexico vs. Marquette 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread cashes in well over 50% of simulations!

So who wins New Mexico vs. Marquette, and which side of the spread cashes in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!