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Nationals vs. Pirates line, odds, start time, pick, best bets for April 15 matchup from proven model

SportsLine's projection model, which is on a profitable 8-3 run, has locked in its MLB picks for the Washington Nationals vs. Pittsburgh Pirates at PNC Park on Tuesday

By@SportsLineUpdated: Apr 15, 2025 7:37PM UTC . 2 min read

The Pittsburgh Pirates and Washington Nationals will continue their four-game series in Pittsburgh on Tuesday after the Pirates defeated the Nationals 10-3 on Monday in the series opener. The Pirates improved to 6-11 overall this season and snapped a three-game losing streak with the win. The Nationals fell to 6-10 overall and have lost three straight games. Paul Skenes had six strikeouts over six innings for the Pirates on Monday.

First pitch from PNC Park in Pittsburgh, Pa., is set for 6:40 p.m. ET. Pittsburgh is a -137 favorite on the money line (risk $137 to win $100) in the latest Pirates vs. Nationals odds, while Washington is a +116 underdog. The over/under is 8.5 (Under -115) in the latest MLB odds via SportsLine consensus.

Before making any Nationals vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 4 of the 2025 MLB season on an 8-3 run on top-rated money-line picks (+340). Anybody following could have seen strong returns!

The model has simulated Nationals vs. Pirates 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!

Who wins Nationals vs. Pirates, and which side of the money line is the better value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on an 8-3 roll on top-rated MLB picks!

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