The No. 16 seed Mount St. Mary's Mountaineers will look to challenge the No. 1 seed Duke Blue Devils in an East Regional first-round matchup Friday. The Mountaineers (23-12), who were 12-8 in the MAAC, are making their seventh NCAA Tournament appearance. The Blue Devils (31-3), who won the ACC regular-season title at 19-1, are making their 47th NCAA Tournament appearance. Duke freshman forward Cooper Flagg (ankle) is expected to play.

Tipoff from Lenovo Center in Raleigh, N.C., is set for 2:50 p.m. ET. Duke is a 32.5-point favorite in the latest Mount St. Mary's vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 140.5. Duke is the -25000 favorite on the money line.

Before making any Mount St. Mary's vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.    

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Mount St. Mary's vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 60% of the time!

So who wins Mount St. Mary's vs. Duke, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!