The Mount St. Mary's Mountaineers will battle the American Eagles in an NCAA Tournament First Four matchup on Wednesday night. The winner will take on top-seeded Duke on Friday.

Tipoff from the University of Dayton Arena in Dayton, Ohio, is set for 6:40 p.m. ET. American is a 2.5-point favorite in the latest Mount St. Mary's vs. American odds from SportsLine consensus, while the over/under for total points scored is 129.5.

Before making any Mount St. Mary's vs. American picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Mount St. Mary's vs. American 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time!

So who wins Mount St. Mary's vs. American, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!