The Detroit Lions will face the Green Bay Packers on Monday Night Football. The Lions lost to the San Francisco 49ers in their season-opener. Detroit stormed back in the final two minutes from a 41-17 deficit to make it a one-score game, but feel short, 41-33. The Green Bay Packers were dominated by the New Orleans Saints from start to finish and lost 38-3.

Green Bay is favored by 11.5 points in the latest Lions vs. Packers odds from Caesars Sportsbook, while the Over-Under is 48.5. Kickoff from Lambeau Field is set for 8:15 p.m. ET. 

Before making any Lions vs. Packers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has set its sights on Lions vs. Packers. We can tell you the model is leaning Under, and it also says one side of the spread cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Lions vs. Packers on Monday Night Football? And which side of the spread cashes well over 50 percent of the time? ... Join SportsLine right now to find out which side of the Lions vs. Packers spread you need to jump on, all from the model on a 121-79 roll on NFL picks!