The sixth-seeded Ole Miss Rebels battle the second-seeded Michigan State Spartans in their South Region Sweet 16 matchup on Friday. The Rebels (24-11), who are 7-9 in 10 NCAA Tournament appearances, are competing in their first Sweet 16 since losing to Arizona in 2001. The Spartans (29-6), who are 75-36 in 38 NCAA Tournaments, are making their second trip to the Sweet 16 in the past three years.

Tipoff from State Farm Arena in Atlanta is set for 7:09 p.m. ET. Michigan State is a 3.5-point favorite in the latest Ole Miss vs. Michigan State odds from SportsLine consensus, while the over/under for total points scored is 144.5. 

Before making any Ole Miss vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Ole Miss vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Ole Miss vs. Michigan State, and which side of the spread hits in nearly 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball picks and has nailed 25 first-round upsets by double-digit seeds!