The penultimate non-CFP bowl game of the season takes place on Friday with the Duke's Mayo Bowl 2025. Minnesota (7-5) will take on Virginia Tech (6-6) in a matchup of Big Ten and ACC programs. The Golden Gophers are seeking a sixth straight bowl victory under head coach P.J. Fleck, while the Hokies are looking for consecutive winning seasons since having 25 straight years over .500 from 1993-2017. The 2025 Duke's Mayo Bowl will be the first-ever meeting between the two schools.

Kickoff is set for 7:30 p.m. ET at Bank of America Stadium in Charlotte, N.C. Minnesota is favored by 10 points in the latest Virginia Tech vs. Minnesota odds via SportsLine consensus, while the over/under is 43 points. 

Before entering any Minnesota vs. Virginia Tech picks or 2025 Duke's Mayo Bowl bets, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it went 43-35 on top-rated picks during the 2024 season. It also nailed all four winners in the first round of the College Football Playoff! Anyone following has seen impressive returns!

Now, the model has simulated Virginia Tech vs. Minnesota 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Minnesota vs. Virginia Tech in the Duke's Mayo Bowl, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!