A Sweet 16 affair has the No. 1 seed Auburn Tigers and the No. 5 seed Michigan Wolverines matching up Friday. The Tigers knocked off the No. 9 seed Creighton 82-70 in the second round. Michigan defeated Texas A&M 91-79 on March 22 to advance to the Sweet 16. 

Tipoff from the State Farm Arena in Atlanta, Georgia, is set for 9:39 p.m. ET. Auburn is an 8.5-point favorite in the latest Michigan vs. Auburn odds from SportsLine consensus, while the over/under for total points scored is 153.5. The Tigers are -424 money-line favorites. 

Before making any Michigan vs. Auburn picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Michigan vs. Auburn 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Michigan vs. Auburn, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 24 double-digit upsets!