The No. 14 Michigan State Spartans host the No. 13 Purdue Boilermakers in an important Big Ten matchup on Tuesday. Michigan State is 20-5 on the season and trails Michigan by one game at 11-3 in the conference, while Purdue is 19-7 overall and sits third in the Big Ten standings at 11-4. 

Tipoff from the Jack Breslin Student Events Center in East Lansing, Mich., is set for 7 p.m. ET. The Spartans are 3.5-point favorites in the latest Purdue vs. Michigan State odds from SportsLine consensus, while the over/under for total points scored is 148.5. Michigan State is the -168 favorite (risk $168 to win $100) on the money line.

Before making any Purdue vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 16 of the 2024-25 season on a 213-158 roll (+1675) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in 60% of simulations!

So who wins Purdue vs. Michigan State, and which side of the spread hits in 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!