The No. 6 Oregon Ducks (4-0, 1-0) look to stay unbeaten when they host the Michigan State Spartans (3-2, 1-1) for a Big Ten matchup at Autzen Stadium on Friday. The Ducks are coming off a dominant 34-13 road win over UCLA. Oregon is 1-3 against the spread in 2024. The Spartans are looking to bounce back from a 38-7 blowout loss to Ohio State. MSU is 2-3 ATS this season. Oregon leads the all-time series 4-3, including a 7-6 neutral site victory in the last meeting in 2018. 

The Ducks are 23.5-point favorites in the latest Oregon vs. Michigan State odds via SportsLine consensus, while the over/under for total points scored is 52.5. Oregon is a -2439 (risk $2,439 to win $100) favorite on the money line, with Michigan State listed as a +1096 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Oregon vs. Michigan State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for Oregon vs. Michigan State in their Week 6 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Michigan State vs. Oregon in their Week 6 matchup in Eugene on Friday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who went 107-45-2, returning $5,790 for $100 bettors, betting on college football in 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates