The SEC and Big Ten will collide in a pair of Friday matchups in the Sweet 16 round of the NCAA Tournament 2025, with the first pitting No. 2 Michigan State against No. 6 Ole Miss. The Rebels defeated First Four team, North Carolina, in the first round before knocking off Iowa State in the Round of 32. Meanwhile, the Spartans easily rolled over Bryant in their 2025 March Madness opener before hanging on to defeat New Mexico in the second round. Michigan State defeated Ole Miss in their lone previous meeting back in the 1999 NCAA Tournament.

Tip-off from the State Farm Arena in Atlanta is set for 7:09 p.m. ET. The Spartans are 3.5-point favorites in the latest Ole Miss vs. Michigan State odds from SportsLine consensus, while the over/under for total points scored is 144.5. The Spartans are -177 on the money line.

Before making any Ole Miss vs. Michigan State picks, you won't want to miss the college basketball predictions from red-hot college basketball expert Bruce Marshall.

For years, the Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. Marshall now supplies his unique and colorful brand of football and basketball analysis to SportsLine members.

Marshall enters the Sweet 16 of the 2025 NCAA Tournament on a 91-61-1 roll (+2329) over his last 153 college basketball picks. He's also excelled with picks in games involving the Ole Miss Rebels and is 10-2 (+772) on his last 12 picks in Ole Miss games. Anybody who's followed his picks could be WAY UP!

For Ole Miss vs. Michigan State, Marshall is leaning Under on the total, and he also found a critical x-factor that has has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Ole Miss vs. Michigan State, and which side of the spread should you back? Join SportsLine right now to see which side of the spread you need to jump on, all from a red-hot college basketball expert that is on a 10-2 (+772) run on his hoops picks involving Ole Miss!