The No. 2 seed Michigan State Spartans will face another double-digit seed when they square off against No. 10 seed New Mexico on Sunday night in the second round of the 2025 NCAA Tournament. Michigan State used a big second half to cruise to an 87-62 win over No. 15 seed Bryant on Friday night. New Mexico upset No. 7 seed Marquette in the first round, notching a 75-66 victory.   

Tip-off from Rocket Arena in Cleveland will be at 8:40 p.m. ET. The Spartans are 6.5-point favorites in the latest New Mexico vs. Michigan State odds, via SportsLine consensus, while the over/under for total points is 148.5, down one from the opening line. 

Before making any New Mexico vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It entered the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated New Mexico vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in almost 60% of simulations!

So who wins New Mexico vs. Michigan State, and which side of the spread hits in almost 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!