The No. 2 seed Michigan State Spartans (27-6) will begin their 27th straight March Madness run when they take on the No. 15 seed Bryant Bulldogs (23-11), the America East Champions, in the first round of the 2025 NCAA Tournament on Friday.

Tipoff from Rocket Arena in Cleveland, Ohio is set for 10 p.m. ET. The Spartans are 17.5-point favorites in the latest Bryant vs. Michigan State odds via SportsLine consensus, while the over/under for total points is 152.5.

Before making any Bryant vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Bryant vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Under and it also says one side of the spread cashes in well over 50% of simulations!

So who wins Bryant vs. Michigan State, and which side of the spread cashes in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!