The No. 6 Miami Hurricanes will look stay undefeated when they hit the road to face the Louisville Cardinals on Saturday at L&N Federal Credit Union Stadium in Louisville. The Hurricanes (6-0, 2-0 in ACC) are tied for second in the ACC, behind only Clemson. They enter the game off a bye. Meanwhile the Cardinals (4-2, 2-1) are coming off a 24-20 comeback victory over Virginia. The win ended a two-game losing streak.

Kickoff is noon ET. The Hurricanes are 5.5-point favorites in the latest Miami vs. Louisville odds, while the over/under for total points scored is 61. (See up-to-date odds for every game this week on our college football odds page.)

Before making any Louisville vs. Miami picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 12-5 on all top-rated picks over the past three weeks of this season. Anyone who has followed it has seen strong returns.

The model knows that the Hurricanes have a Heisman Trophy contender at quarterback in Cam Ward. The transfer from Washington State leads the country in multiple categories, including total offense (396.7 yards per game), passing yards per game (369.8) and passing touchdowns (20). Led by Ward, Miami leads the nation in both scoring offense (47.7 points per game) and total offense (583.8). 

But the model also has taken into account that the Cardinals have owned the head-to-head series recently against Miami. Louisville has won four of the last six meetings. That includes a 38-31 win last season in Miami.

For Saturday, the model has set its sights on Miami vs. Louisville. We can tell you it is leaning Under the total, projecting a combined 60 points. It also says one side of the spread hits well over 50% of simulations. You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Louisville vs. Miami, and which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Miami vs. Louisville spread you should be all over Saturday, all from the model on a roll on college football picks!