The No. 16 Memphis Tigers will try to secure an outright American Athletic Conference regular-season title when they host the South Florida Bulls on Friday night. Memphis has already earned a share of the title and the No. 1 seed in the upcoming AAC Tournament after beating UTSA on Tuesday. South Florida has lost six of its last seven games, including an 80-65 setback in the first meeting between these teams this season.  

Tipoff is set for 9 p.m. on Friday at the FedExForum. Memphis is favored by 12.5 points in the latest Memphis vs. South Florida odds, while the over/under is 152.5 points, per SportsLine consensus. Before entering any South Florida vs. Memphis picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 betting roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen HUGE returns.

The model has simulated Memphis vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Memphis vs. South Florida? And which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.