The 16th-ranked Clemson Tigers will take on the Memphis Tigers in a key non-conference matchup on Saturday. Clemson earned a 65-55 win at Miami on Dec. 7, while Memphis dropped an 85-72 decision to Arkansas State on Sunday. Memphis (7-2), which tied for fifth in the American Athletic Conference at 11-7 and was 22-10 overall in 2023-24, has lost two of three but is 1-0 on the road this year. Clemson (9-1), which tied for fifth in the Atlantic Coast Conference at 11-9 and was 24-12 overall last season, has won six in a row and is 6-0 on their home court.

Tip-off from Littlejohn Coliseum in Clemson, S.C., is set for 11 a.m. ET. Clemson is a 6.5-point favorite in the latest Memphis vs. Clemson odds from SportsLine consensus, while the over/under for total points scored is 143.5. 

Before entering any Clemson vs. Memphis picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 6 of the 2024-25 season on a 174-125 roll (+2196) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

Now, the model has simulated Memphis vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it's also generated a point-spread pick that hits in well over 70% of simulations!

So who wins Memphis vs. Clemson, and which side of the spread hits well over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!