The 12th-ranked McNeese Cowboys will look to register their second consecutive upset win when they battle the fourth-seeded Purdue Boilermakers in a Midwest Regional second-round matchup on Saturday afternoon. The Cowboys (28-6), who are 1-3 all-time in the NCAA Tournament, have allowed fewer than 70 points in 27 games this season, the most in the Southland Conference. The Boilermakers (23-11), who are 50-35 all-time in the tournament, are making their 10tth consecutive appearance and 16th in 20 seasons under coach Matt Painter.

Tipoff from Amica Mutual Pavilion in Providence, R.I., is set for 12:10 p.m. ET. Purdue is a 6.5-point favorite in the latest McNeese vs. Purdue odds from SportsLine consensus, while the over/under for total points scored is 142.5. 

Before making any McNeese vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated McNeese vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in almost 70% of simulations!

So who wins McNeese vs. Purdue, and which side of the spread cashes in almost 70% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!