A massive top-25 college basketball matchup will take place on Tuesday when the No. 15 Marquette Golden Eagles host the No. 6 Purdue Boilermakers. Marquette is coming off a Sweet 16 appearance a season ago and is off to a 4-0 start while Purdue went to the national championship game last season and is also 4-0 in 2024-25. Now the two titans will battle it out for the third season in a row, with the Boilermakers winning both matchups but the Golden Eagles going 1-0-1 against the spread in those meetings.

Tip-off from Fiserv Forum in Milwaukee is set for 9 p.m. ET. The Golden Eagles are 5-point favorites in the latest Marquette vs. Purdue odds from SportsLine consensus, while the over/under for total points scored is 153. Before entering any Purdue vs. Marquette picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 3 of the 2024-25 season on a 156-114 roll (+1762) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Marquette vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting well over 50% of the time!

So who wins Purdue vs. Marquette? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!