The series between the Seattle Mariners (9-9) and the Cincinnati Reds (9-9) comes to a close on Thursday afternoon. These teams split the first two contests, with the Mariners taking away a 5-3 victory on Wednesday. Brady Singer (3-0, 3.18 ERA) starts for the Reds. Bryan Woo (2-0, 2.84 ERA) gets the nod for Seattle. 

First pitch is scheduled for 12:40 p.m. ET at Great American Ball Park in Cincinnati, Ohio. The Reds are the -135 money line favorites (bet $135 to win $100) in the latest Mariners vs. Reds odds, while the Mariners are +115 underdogs (bet $100 to win $115). The over/under for total runs scored is 9 in the latest MLB odds. 

Before you make any Mariners vs. Reds picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 3 of the 2025 MLB season on a 34-19 roll on top-rated run-line MLB betting picks (+629). Anybody following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Mariners vs. Reds 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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